Scientific References

These studies concern saffron supplementation or studied extracts, not necessarily the culinary saffron products sold here. The findings are preliminary or mixed and do not establish medical benefits of these products. This information is not medical advice.

1. Setayesh, Leila, Damoon Ashtary-Larky, Cain C. T. Clark, Mahnaz Rezaei Kelishadi, Pardis Khalili, Reza Bagheri, Omid Asbaghi, and Katsuhiko Suzuki. “The Effect of Saffron Supplementation on Blood Pressure in Adults: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.” Nutrients 13, no. 8 (2021): 2736. https://doi.org/10.3390/nu13082736
2. Zamani, Mohammad, Mahtab Zarei, Mahlagha Nikbaf-Shandiz, Fatemeh Gholami, Amir Mehdi Hosseini, Maryam Nadery, Farideh Shiraseb, and Omid Asbaghi. “The Effects of Saffron Supplementation on Cardiovascular Risk Factors in Adults: A Systematic Review and Dose-Response Meta-Analysis.” Frontiers in Nutrition 9 (2022): 1055517. https://doi.org/10.3389/fnut.2022.1055517
3. Marx, Wolfgang, Melissa Lane, Tetyana Rocks, Anu Ruusunen, Amy Loughman, Adrian Lopresti, Skye Marshall, Michael Berk, Felice Jacka, and Olivia M. Dean. “Effect of Saffron Supplementation on Symptoms of Depression and Anxiety: A Systematic Review and Meta-Analysis.” Nutrition Reviews 77, no. 8 (2019): 557–571. https://doi.org/10.1093/nutrit/nuz023
4. Mahmoudi, Roya, Mohsen Mohammadi-Sartang, Karo Servatyari, and Nastaran Rafieipour. “Effect of Saffron on Depression, Anxiety and Mood Disorder: A GRADE Assessed Systematic Review and Meta-Analysis of 34 Randomized Controlled Trials.” Nutritional Neuroscience 29, no. 7 (2026): 816–837. https://doi.org/10.1080/1028415X.2025.2602153
5. Lian, Jinrong, Yi Zhong, Hang Li, Siyuan Yang, Jiahe Wang, Xiang Li, Xinmin Zhou, and Gang Chen. “Effects of Saffron Supplementation on Improving Sleep Quality: A Meta-Analysis of Randomized Controlled Trials.” Sleep Medicine 92 (2022): 24–33. https://doi.org/10.1016/j.sleep.2022.03.001
6. Rafiei, Seyyed Kiarash Sadat, et al. “Saffron and Sleep Quality: A Systematic Review of Randomized Controlled Trials.” Nutrition and Metabolic Insights 16 (2023): 11786388231160317. https://doi.org/10.1177/11786388231160317